NYSE Euronext saw Q1 profits fall by 32 per cent to $121m and revenue fall 17 per cent to $952m.
The stock exchange operator said derivatives trading dropped in London by 28% and share trading volumes also fell.
"Our first quarter results reflect the challenging operating environment which carried over into 2012 and will continue to result in near-term headwinds," said Duncan Niederauer, Chief Executive of NYSE Euronext.
NYSE was forced to drop a planned merger with Deutsche Borse in February after the European Commission objected on competition grounds. This failed merger cost the company $36m.
Other operating expenses, excluding merger expenses and exit costs, were
NYSE Euronext is building out its colocation business across the world through a fleet of Liquidity Centers and a growing service portfolio.